Everything about Tgf Beta Receptors totally explained
TGFβ receptors are single pass
serine/threonine kinase receptors. They exist in several different
isoforms that can be
homo- or
heterodimeric. The number of characterized ligands in the TGFβ superfamily far exceeds the number of known receptors, suggesting the promiscuity that exists between the
ligand and receptor interactions.
TGF can be found in many different
tissue types, including brain,
heart,
kidney,
liver and
testes. Over-
expression of TGF can induce
renal fibrosis, causing
kidney disease, as well as
diabetes, and ultimately
end-stage renal disease (ESRD). Recent developments have found that, using certain types of protein
antagonists against TGFβ receptors, can halt and in some cases reverse the effects of renal fibrosis.
Classification
Three TGF-β receptor types can be distinguished by their structural and functional properties. Receptor types I and II have similar ligand binding affinities and can only be distinguished from each other by
peptide mapping, both receptor types I and II have a high affinity for
TGF-β1 and low affinity for
TGF-β2. TGF-β receptor type III has a high affinity for both TGF-β1 and -β2 and in addition TGF-β1.2.
Types
Further Information
Get more info on 'Tgf Beta Receptors'.
|
External Link Exchanges
Do you know how hard it is to get a link from a large encyclopaedia? Well we're different and will prove it. To get a link from us just add the following HTML to your site on a relevant page:
<a href="http://tgf_beta_receptors.totallyexplained.com">TGF beta receptors Totally Explained</a>
Then simply click through this link from your web page. Our crawlers will verify your link, extract the title of your web page and instantly add a link back to it. If you like you can remove the words Totally Explained and embed the link in article text.
As long as your link remains in place, we'll keep our link to you right here. Please play fair - our crawlers are watching. Your site must be closely related to this one's topic. Any kind of spamming, dubious practises or removing the link will result in your link from us being dropped and, potentially, your whole site being banned. |
